Located at the Faculty of Pharmaceutical Sciences in Vancouver
Williams Lab Research Highlights
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Liquid Biopsy for Cancer
N Salmond, KC Williams.. Isolation and characterization of extracellular vesicles for clinical applications in cancer – time for standardization? Nanoscale Advances 3, 1830-1852
K Khanna, N Salmond, KS Lynn, HS Leong, KC Williams. Clinical significance of STEAP1 extracellular vesicles in prostate cancer. 2021 Sep;24(3):802-811.
N Salmond, K Khanna, GR Owen, KC Williams. Nanoscale flow cytometry for immunophenotyping and quantitating extracellular vesicles in blood plasma. Nanoscale 13, 2012-2025.
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Mechanisms and Markers of Tumor Cell Metastasis
S Soukhtehzari, RB Berish, L Fazli, PH Watson, KC Williams. The different prognostic significance of polysialic acid and CD56 expression in tumor cells and lymphocytes identified in breast cancer. NPJ Breast Cancer 8 (1), 78
Williams KC, Cepeda MA, Javed S, Searle K, Parkins KM, Makela AV, Hamilton AM, Soukhtehzari S, Kim Y, Tuck AB, Ronald JA, Foster PJ, Chambers AF, Leong HS.. Invadopodia are chemosensing protrusions that guide cancer cell extravasation to promote brain tropism in metastasis. Oncogene 38 (19), 3598-3615
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Technology and Model Development
K Khanna, N Salmond, S Halvaei, A Johnson, KC Williams. Separation and isolation of CD9-positive extracellular vesicles from plasma using flow cytometry. Nanoscale Advances, 4435-4446
N Salmond, K Khanna, GR Owen, KC Williams. Nanoscale flow cytometry for immunophenotyping and quantitating extracellular vesicles in blood plasma. Nanoscale 13, 2012-2025.
S Javed, S Soukhtehzari, N Salmond, N Fernandes, KC Williams. Development of an in vivo system to model breast cancer metastatic organotropism and evaluate treatment response using the chick embryo. iScience 26 (4).
S Javed, S Soukhtehzari, N Fernandes, KC Williams.Longitudinal bioluminescence imaging to monitor breast tumor growth and treatment response using the chick chorioallantoic membrane model. Scientific reports 12 (1), 17192.